Up to date, no study has assessed the overall effects of TG on CVDs death or all-cause death by including all eligible studies in the world. < 1.7 mmol/L) was associated with an increased risk of CVDs (but not all-cause) moratity in women and men. Another collaborative analysis including 10,269 participants from 7 studies in Europe, reported that higher triglyceride (≥ 1.7 versus. The collaboration studies from the Asia Pacific Cohort Studies Collaboration (APCSC) suggested that elevated TG levels were strongly associated with an increased mortality of coronary heart disease (CHD). updated the overall effect of TG on CVDs incidence but not for CVDs mortality. reported the summary crude RR for and CVDs death in the sensitive analysis of a meta-analysis assessing the association of TG with CVDs incidence, in which seventeen prospective studies of American and European participants were included. Several reviews and meta-analyses evaluated the association between blood TG and mortality. There is considerable evidence to suggest that triglycerides (TG) play a role in such adverse health conditions as heart disease, peripheral vascular disease, stroke, diabetes mellitus, metabolic syndrome, and cancer, which are common causes of death. In conclusion, elevated blood TG levels were dose-dependently associated with higher risks of CVDs and all-cause mortality. The risks of CVDs and all-cause deaths were increased by 13% and 12% (p < 0.001) per 1-mmol/L TG increment in twenty-two and twenty-two studies reported RRs per unit TG, respectively. Twelve and fourteen studies, respectively, reported the effects estimates of CVDs and total mortality by TG categories. We identified 61 eligible studies, containing 17,018 CVDs deaths in 726,030 participants and 58,419 all-cause deaths in 330,566 participants. Risk ratios (RRs) with 95% confidence intervals (CIs) were extracted and pooled according to TG categories, unit TG, and logarithm of TG using a random-effects model with inverse-variance weighting. All prospective cohort studies reporting an association between TG and CVDs or all-cause mortality published before July 2013 were included. Four databases were searched without language restriction for relevant studies: PubMed, ScienceDirect, EMBASE, and Google Scholar. The aim of this study was to determine the associations between blood triglyceride levels and cardiovascular diseases (CVDs) mortality and all-cause mortality. The relationship of triglycerides (TG) to the risk of death remains uncertain.
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